N-GAMe: NSABP Genome Assessment Guided Medicine Program
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N-GAMe: NSABP Genome Assessment Guided Medicine Program

Metastatic colorectal cancer, cancer that has returned or spread from the place it first started, remains largely incurable although advances have been realized with chemotherapeutic combinations.  The newer targeted therapies are newer types of cancer treatment that uses drugs or other substances to more precisely identify and attack cancer cells.

NSABP Foundation, Inc. is sponsoring MPR-1. MPR-1 is part of a research program started by NSABP called the NSABP Genome Assessment Guided Medicine (N-GAMe) program to find treatment protocols that are specific for people with certain types of cancer.

The purpose of MPR-1 is to do genetic tests on samples of tissue, including tumor tissue, and if available, normal tissue, that have already been removed from patients during a previous surgery.  A patient's tumor and normal tissue samples will be tested for genetic changes.  Normal tissue and tumors are made up of cells and within cells are genes.  While genes are inherited from your parents, genes may also undergo changes throughout your life.  All genes contain DNA.  DNA codes (sequences) within genes are the instructions that tell our bodies how to grow and work and that make physical characteristics such as hair and eye color.  Cancer can result from changes in genes that cause cells to rapidly multiply in an uncontrolled way.These genetically changed cells can travel and multiply in other parts of the body (metastasize).  Genetic changes in cells can also change the way certain types of cancer respond to treatments.  At this time, researchers and doctors know some, but not all, of the genetic changes that can cause cancer and can affect how certain cancers respond to specific treatments.

The samples will be tested at NSABP for genetic changes and/or other changes in your tissues. These types of tests will also be done at other specialty laboratories designated by NSABP. Some of these tests will be done soon after collection of the patient's tissue samples and other tests will be done in the future.  Future tests may include additional genetic tests and/or tests that look at other changes in your tissues. The main purpose of doing tests on tissue samples is to find genetic changes associated with a patient's type of cancer. The information from the genetic tests, along with a patient's health information, will be used to help find an appropriate treatment trial for the patient if one becomes available.