NSABP Biospecimen Discovery Project
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NSABP Biospecimen Discovery Project

The purpose of this study is to discover genetic and protein changes associated with cancer. This should lead to better ways to prevent, detect, and treat cancer and, perhaps, other health problems as well.

Body tissues are made up of cells. Cells contain DNA, which is an individual's unique genetic code that carries the instructions for making proteins, which are important for a person's body’s development and function. DNA can be specially tested (sequenced) so that the exact genetic code that a person has can be identified. By using this sequencing technique, we will be able to detect changes in DNA that are unique to that individual and their cancer. Currently, researchers and doctors know some of the genetic and protein changes that can cause cancer, and that cause cancer cells to travel to other organs, but they do not know all of these genetic and protein changes.

This study is designed to find genetic and proteins changes that can cause cancer. We will compare the genetic and protein material from a patient's cancer tissue with the normal genetic material in their blood in order to find the differences that exist in their normal tissue. We will also compare changes that happen in proteins and genetic material in their tumor tissue collected before and at 48 to 72 hours after their first chemotherapy/targeted therapy treatment dose in order to find the changes that treatment causes in the cancer cells. By studying this information, it may be possible to identify the genetic changes that happen with a patient's particular type of cancer. This type of information may help us find out why some tumors respond well to chemotherapy and targeted therapy treatments and others do not. In the future, this information could allow treatments for breast cancer to be customized to a patient's own genetic make-up.